Severeside effectscan lead to injury or death -drowsinesscan cause a car accident or injury when operating heavymachinery. Here we look at how Injectafer and Venofer are alike and different. In order for your body to make RBCs, your bone marrow needs a hormone called erythropoietin (EPO). Iron is also necessary for your bone marrow to build healthy new red blood cells and provide oxygen to your . The benefit of treating your condition during pregnancy may outweigh any risks. Before using iron sucrose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. ByDr. Note: The Food and Drug Administration (FDA) tracks side effects of drugs they have approved. The actual price youll pay depends on your insurance plan and any copays, your location, and the pharmacy you use. If you have iron deficiency anemia (IDA), consuming moderate amounts of alcohol may be safe, if your doctor tells you its OK. (With IDA, you have a low level of red blood cells thats caused by not having enough iron.). Possibleside effectsareweight gainand suicidal thoughts. chest pain. Your doctor will be able to see how Venofer is working by reviewing your blood tests. Learn about uses, cost, how it works, and more. * Sex and gender exist on spectrums. Side effectswill last a very long time if the cause of them is not resolved. Some drugs may have another patient information leaflet. Foods rich in iron include meats (especially liver), eggs, raisins, figs, broccoli, brussels sprouts, beans, lentils, and iron-fortified or enriched cereals. Youll receive doses of either drug by a healthcare professional at a medical facility. Its responsible for carrying oxygen throughout your body. Otherwise, call a poison control center right away. taste impairment. Before approving coverage for Injectafer, your insurance company may require you to get prior authorization. But its not known whether this poses any risk to a child whos breastfed. Injectafer should be stored between 68F to 77F (20C to 25C). The time it takes to infuse Venofer (iron sucrose) depends on your age, if you're on dialysis, and the type of dialysis you need. The Food and Drug Administration (FDA) approves prescription drugs such as Injectafer to treat certain conditions. Iron sucrose injection has a molecular weight of approximately 34,000 - 60,000 daltons and a proposed structural formula: Cholesterolmedication may reduce the risk of a stroke but it can decrease the quality of life for some people but causingweight gain, dizziness, nausea, and musclepain. Best food forward: Are algae the future of sustainable nutrition? <> If you come into contact with Red Tide, it can cause respiratory irritation, coughing, and sneezing. The drug helps increase your hemoglobin level back to a value thats within the normal range. Heart failure: Could a low sodium diet sometimes do more harm than good? In the studies, peoples hemoglobin level was measured to check for improvement in their anemia. In clinical studies, Injectafer was effective in treating IDA in adults who either didnt improve with or had side effects from taking iron by mouth. Both Injectafer and Feraheme belong to a class of medications known as iron replacement products. How long does iron infusion stay in your system? For more information about Injectafers approved uses, see the section Injectafer uses below. Also tell them about any vitamins, herbs, and supplements you use. These lists contain up to 10 of the most common mild side effects that can occur with Injectafer, with Feraheme, or with both drugs (when taken individually). And these two doses need to be separated by at least 7 days. The Role of Genetics in Multifactorial Disorders, The Power of DNA Testing and Predictive Medicine, A Guide to Genome Explorer (Free Version), Whole Genome Sequencing in As Little As Three Weeks, What Diseases Can Be Detected Through Genetic Testing, Breast Cancer Genetic Testing: Pros and Cons, At Home Genetic Testing for Breast Cancer, DNA Tests for Breast Cancer Genetic Testing, What to Do When Medicines Have Side Effects, Blood Type and COVID: Infection Risk and Severity, Where Can I Get My Blood Type Checked for Free, How to Find Biological Father Through DNA. Details. Mental healthdisorders like depression may requireantidepressantsto treat. There have also been reports of serious allergic reactions to Venofer. The recommended dosing guidelines of Injectafer for treating IDA are based on patient weight, as follows: Injectafer contains ferric carboxymaltose, which is a polymer that releases iron into the body. People who weigh less than 110 lb (about 50 kg) will receive two separate Injectafer doses of 15 mg/kg of body weight. stream Throw away unused or expired drugs. The information provided is not intended to replace your healthcare provider's medical advice. Dr. Brandon ColbyMDis a US physician specializingin the personalized prevention of disease through the use of genomic technologies. Someside effectsare temporary or last as long as the person continues takingprescription medicine. Serious side effects from Injectafer arent common, but they can occur. If you have questions about side effects, call your doctor. Find comprehensive medical information for Venofer intravenous on RxList including its uses, side effects, precautions, drug interactions, overdose, pill images & warnings . WebMD provides common contraindications for Venofer Vial. If your symptoms or health problems do not get better or if they become worse, call your doctor. Consult the product instructions and your pharmacist for storage details. This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. An example of a drug interaction that many people are not aware of isgrapefruitjuice and statins. Examples of thisinclude: Not allside effectslast forever. Call your doctor for medical advice about side effects. fever, cold or flu symptoms (sore throat, cough, stuffy nose, sneezing); bruising or irritation where the medicine was injected. Symptoms of a severe allergic reaction can include: Because of the risk of allergic reaction with Injectafer, your healthcare professional will monitor you for at least 30 minutes after you get each dose of the drug. This is why family members often have the same issues with drugs as others in theirfamily. If you need financial support to pay for Injectafer, or if you need help understanding your insurance coverage, help is available. Your doctor may also recommend that you take iron supplements by mouth (if you havent tried these supplements in the past). This gives a total cumulative dose of 1,500 mg of Injectafer. Your body then uses the iron from Injectafer to make hemoglobin and new RBCs. No, you wont need to take iron pills while youre using Injectafer. Drug interactions may change how your medications work or increase your risk for serious side effects. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. You may also report side effects at https://www.fda.gov/medwatch. But you likely wont feel the drug working inside of you. Your dosage and length of treatment are based on your medical condition, age, and response to treatment. However, since peoples bodies react so differently to drugs, they often have to change their stance on certaindrugs. After getting each dose of Injectafer, your healthcare professional will monitor you for at least 30 minutes. Data on file, American Regent, Inc. 1. Feraheme also comes as a liquid thats given by IV infusion. Patients should induce vomiting or evacuate the stomach by lavage during Venofer overdoasge. I can't take oral supplements because they cause horrible debilitating Constipation. Be ready to tell or show what was taken, how much, and when it happened. In this group, after 35 days of treatment: Effectiveness of Injectafer compared with a different IV iron product. Keep in mind that the risk of certain pregnancy-related problems can be increased if iron deficiency anemia (IDA) is left untreated. Side effectsare uncomfortable reactions to medications or drugs. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. * Feraheme has a boxed warning for this side effect. What Is the Cost of Whole Genome Sequencing (WGS)? pain in the arms or legs. It can be given as a slow injection over 2 to 5 minutes or as an infusion. Injectafer isnt available in a generic form. Injectafer isnt known to interact with any other medications, herbs, supplements, or foods. 1xo`[kg'#KS#.#`uv:PM1+Ob`>y/8:6Ghl:y9B+-,9m[ reactions at the site of the injection. (A medication class describes a group of drugs that work in the same way.). intense abdominal pain. IQVIA [NSP Audit from MAT November 2013 to November 2018]. Its not known how often people taking a treatment other than Injectafer had diarrhea. If you think there has been an overdose, call your poison control center or get medical care right away. These are not all the side effects that may occur; contact your healthcare provider if you have questions. fever. This test measures the amount of hemoglobin in your blood. }|54U|O~?|_v;f\o^(W+/-|^)O65_)rd sm }[x[)y.z Wz?9_jV0ub,`g`s?oXOSp/Kgw$b!Vb$;IvBVR9n|\0ln=;/=,mgw@do,[";/8nJL{n}Bb-|^6[~>a_1H'^M:^vv=iM+x|+Y You may wonder how Injectafer compares with other medications that are prescribed for similar uses. Learn how to store and discard medical supplies safely. upper respiratory infection. Is the ketogenic diet right for autoimmune conditions? <> Keep all drugs out of the reach of children and pets. If you notice any changes to your normal blood pressure, call your doctor right away. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. If you have symptoms of a low phosphorus level, call your doctor. Phosphorus is an electrolyte that your body needs in order to make energy. Once you have waited for 30 minutes after the injection, you may go home, providing you are feeling well. So the goal of anemia treatment is to increase your hemoglobin level back to a value thats within a normal range. A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. Use of the term female in this article refers to sex assigned at birth. Venofer injection contains iron sucrose, a form of the mineral iron. Do not flush down a toilet or pour down a drain unless you are told to do so. People from different ethnic backgrounds process medications differently. Constipation,dry mouth, headaches, upset stomach, and many othercommonside effectscan greatly affect peoples quality of life, though. This is a sudden response affecting the entire body, which sometimes happens to people who are allergic to peanuts or beestings. Most people do not know how long theirside effectswill last until they go through them. While the side effects that occur during treatment with these drugs are increasingly well-cataloged, the long-term side effects that may result from receiving these drugs are only beginning to be studied. For people weighing less than 50 kg, administer Injectafer in two doses of 15 mg/kg of body weight, at least 7 days apart. With IDA, you have anemia (low red blood cell level) thats due to not having enough iron in your body. Daiichi Sankyo, Inc., the manufacturer of Injectafer, offers a program called injectconnect, which may help lower the cost of the drug. Call your doctor right away if you have serious side effects. Pain in your limbs. Venofer® (iron sucrose injection, USP) is available by prescription only. These symptoms can include: While youre taking Injectafer, your doctor will monitor your phosphorus levels if youre at risk for hypophosphatemia. Injectafer is a brand-name prescription drug. Remember that it is best to get your vitamins and minerals from food whenever possible. Read all information given to you. Those going through thismedical conditionshould speak to theircare teamfor support andguidance. I had my first infusion of 1gm 10 days ago. Most of these side effects may go away within a few days or a couple of weeks. VenAccess is a trademark of Vifor (International) Inc. Switzerland. Follow all instructions closely. Iron infusion side effects vary depending on which form is being used. One class of immune checkpoint inhibitors targets the protein PD-1, which acts as a brake to keep the immune system in check. After receiving IV iron therapy, you will be monitored for 30 minutes to make sure you do not have an allergic reaction or a drop in blood pressure. If you have any questions about Venofer, please talk with your doctor, nurse, pharmacist, or other health care provider. Iron is a vital mineral in the body, central to transporting oxygen around the body in the hemoglobin. Theyll recommend how to manage your condition. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. This treatment course is split into two doses of the drug, which are given at least 7 days apart. endobj With IDA, you have low hemoglobin levels. You may report side effects to the FDA at 1-800-332-1088. Some people may also experience skin irritation from the adhesive tape and other medical equipment used during the procedure. Injectafer contains the active drug ferric carboxymaltose. Reblozyl is a brand-name prescription medication used to treat anemia in certain blood disorders. If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre taking Injectafer. However, there has been a report of delayed allergic reaction in someone receiving a second dose of Injectafer. (One treatment course includes two doses of the drug.) Venofer may reduce the absorption of iron preparations taken by mouth. In the US - Call your doctor for medical advice about side effects. Last reviewed . Storage Condition Store in a cool and dry place protected from light. (A generic drug is an exact copy of the active drug in a brand-name medication.) For more information about taking Injectafer during pregnancy, see the section Injectafer and pregnancy above. Your doctor will do laboratory tests to monitor your response. 2 0 obj In fact, Injectafer is meant for some people whose anemia didnt improve with iron pills or for people who had side effects from iron pills. Last updated August 20, 2020. In clinical studies, diarrhea was reported in less than 1% of people taking Injectafer. Additional studies are ongoing to see if Injectafer is a safe and effective treatment option for these conditions. You may wonder how Injectafer compares with other medications that are prescribed for similar uses. You are encouraged to report side effects to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. Venofer is manufactured under license from Vifor (International) Inc., Switzerland. Any long-term side effects/dangers from iron infusions? If needed, theyll recommend treatment, including certain medications. This includes your doctors, nurses, pharmacists, and dentists. There are currently no generic forms of either drug. In the first group, some people continued taking iron by mouth, while other people took Injectafer. The body cannot metabolize such a high dose fast enough, so it ends up affecting a part of the body it wasnt intended to, such as the stomach. It depends. The potential side effects of Daxxify are nearly identical to that of Botox bruising, headaches, and droopy eyelids with one big difference: They could last longer. However, to be safe, tell your doctor or pharmacist about all prescription, over-the-counter, and other drugs you take before taking Injectafer. This medicine is sometimes given slowly, and the infusion can take up to 2.5 hours to complete. Most mild side effects of Injectafer typically go away within about 30 minutes of receiving your dose of the drug. Some people are simply allergic to an active ingredient in the medication, so the body responds undesirably. Ask your doctor or healthcare provider if Venofer is the right choice for you. Vomiting. In clinical trials, pregnant females* who took Injectafer didnt have any negative outcomes, such as premature delivery or pregnancy loss. Allergic reaction As with most drugs, some people can have an allergic reaction after taking Injectafer. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. After getting one treatment course of Injectafer, you typically wont need another dose of the drug again unless your anemia comes back. Many people believe they are suffering fromside effectsand may actually be suffering from anothermedical condition, such as havingdifficulty breathingorshortness of breath, which could be a heartattack. But some people have a delayed allergic reaction to certain drugs. This website is intended for use by US healthcare professionals only. (And Injectafer is used to treat IDA.) Can diet help improve depression symptoms? 3 0 obj Many patients with kidney disease cannot get enough iron from food and require injections. These effects typically last between 7 and 11 hours. You should not receive Venofer if you have known allergies to iron sucrose. TheNational Instituteof Health (NIH) and the U.S.Food and Drug Administration(FDA) monitor the side effectsof new and approved medications to ensure safety. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. <> With IV infusion, the drug is given as a slow drip into your vein over a period of time. This is only a brief summary of general information about this medicine. It is very important that your doctor check you closely while you are receiving this medicine. Some may be a better fit for you than others. Call your doctor for medical advice about side effects. You will be watched closely by your doctor for 30 minutes after each dose. Treatment with Venofer injections can make it harder for your body to absorb iron medications you take by mouth. Most people will metabolize medication by half every time it circulates the body. Below are examples of these side effects. The infusion concentration should not be less than 2 mg of Injectafer per mL of solution. This can be very helpful in . Both of theseside effectscould worsen depression and lead tolife-threateningconsequences. Although a single administration of FCM frequently causes transient hypophosphatemia, a 2016 study showed that repeated treatment with FCM is associated with a high risk of developing severe and prolonged hypophosphatemia and should therefore be monitored. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Orofer S 50 Injection 1 Injection in 1 Packet 147. Spacing your Injectafer doses out at least 7 days helps to reduce your risk of side effects. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. One of the most commonly used tests to monitor IDA is the hemoglobin test. Iron sucrose can make it harder for your body to absorb iron medications you take by mouth. In the second group, some people switched from taking iron by mouth to taking Injectafer. Notify your healthcare provider of all medical conditions and any medications, including supplements you are taking. Mild side effects of Injectafer can include:*. Things to remember when you fill your prescription. Usually, when drugs may cause an immune system reaction like this, its a concern with your first dose of the drug. Selected from data included with permission and copyrighted by First Databank, Inc. This is not a complete list of side effects and others may occur. 2. Excessive amounts of Venofer may lead to a condition called iron overload, which may be harmful. All of the people took iron by mouth for 2 weeks. This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. (Hemoglobin is a protein thats found inside your red blood cells.). However, diarrhea it isnt very common in people using Injectafer. Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. In this group, after 35 days of treatment: In clinical studies, Injectafer was effective in treating IDA in adults with CKD who didnt require dialysis. With this condition, you also have a low hemoglobin level. However, many people have no side effects or only have minor side effects. Nausea. (IV iron is absorbed by the body more rapidly than oral iron.) Only 10 mg may be excreted by the body the next time it goes through the liver, and possibly only 5 mg the nextpass. All rights reserved. Signs of high or low blood pressure like very bad headache or dizziness, passing out, or change in eyesight. Potential injection site discoloration has happened. Cardiovascular health: Insomnia linked to greater risk of heart attack. During pregnancy, this medication should be used only when clearly needed. Dizziness. With IDA, you have low hemoglobin levels. . Cancer patients who have anemia and are taking an ESA. Amounts of iron ingested by the infant would be normal and are not expected to cause any adverse effects in breastfed infants. This way, if you have an allergic reaction to Injectafer, your healthcare professional can treat your reaction. Injectafer and Venofer are both brand-name drugs. If youre interested in finding an alternative to Injectafer, talk with your doctor. However, some people can experienceside effectsfor much longer - days, months, or indefinitely. Check with your pharmacist if you have questions about the best way to throw out drugs. Renal elimination is negligible. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Venofer. But so far I feel better than before the infusion. Injectafer and Feraheme can cause very similar side effects, but some different ones as well. But for most people whove developed hypophosphatemia with Injectafer, the condition resolved within 3 months. (A generic drug is an exact copy of the active drug in a brand-name medication.). Weight influences how fast medication breaks down in the body, so it also affects how longside effectswill last. Now I've just got mild nausea and have felt faint/dizzy a few times which is rare for me. But for other people, their IDA returns after treatment with Injectafer. If you are allergic to Venofer; any part of this medicine; or any other drugs, foods, or substances. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Phosphorus also helps your nerves function properly. If you have questions about using Injectafer in a child, talk with your doctor. Together, they can recommend ways to help you manage a body weight thats healthy for you. Its not known how common delayed allergic reaction might be in other people using Injectafer. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Before using, check this product visually for particles or discoloration. Suffering from somemedical conditionsput people at risk fordrugside effectsof medications for other health concerns. These drugs have been compared in a clinical trial of adults with both IDA and CKD who didnt need dialysis. The use of Injectafer and Feraheme in treating IDA in these adults has been directly compared in a clinical study. Dr. Colby is alsothe Founder of Sequencing.com and the authorofOutsmart Your Genes. You may report side effects to FDA at 1-800-FDA-1088. Hypophosphatemia risk appears to be substantially lower with other IV iron formulations. Your doctor will monitor your hemoglobin level to tell if Injectafer is working for you. After 5 weeks of treatment: This study didnt determine if either drug was better than the other. 2023 Medicine.com All rights reserved. Keep all drugs in a safe place. This site is intended for use only by US patients. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Venofer only for the indication prescribed.

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